Once you’re well into the Diablo 4 endgame, you quickly learn it’s not just about killing everything you see. It’s about making every run count. You want XP fast, gear that actually matters, and those big-ticket Uniques without wasting time.

One trick savvy players use is focusing on specific monster types with better odds for certain drops. Husks, for example, have a higher chance of dropping pants. Sounds weird, but if you’re chasing a big upgrade in that slot or hunting for top-tier ancestral leggings, it makes sense. The best hunting ground for Husks is in Hawezar, especially spots like the Dismal Foothills or Fethis Wetlands. Run loops out in the open world or, even better, hit a Nightmare Dungeon in that region so you’re pushing glyphs while cashing in on extra pants drops. And hey, you’ll need gold along the way—Diablo 4 gold keeps the grind moving.

Now for the real chase—Unique items. Sure, they can drop anywhere, off any elite or chest, but banking on randomness can fry your patience. The smarter move is target farming bosses. Endgame bosses have fixed loot tables, so they only drop certain Uniques. Say you’re after the Penitent Greaves—Grigoire, The Galvanic Saint is your guy. To summon him, you’ll need Living Steel from Tortured Gift chests during Helltides. That gives you a clear loop: farm Helltides, grab your materials, take him down. It’s much more focused than wandering around hoping for luck.

Same deal with Lord Zir. He’s tied to Exquisite Blood, which you pick up from World Bosses and Legion Events, and he’s got his own unique drop pool. Then there’s Duriel, King of Maggots. He’s the guy with the smallest but most valuable loot list—those ridiculous “uber” Uniques. Getting him to spawn means you’ve got to take out Grigoire and Varshan first to collect what you need. It’s a chain, but one that’s worth the payoff if your build demands the rarest gear.

The best strategy? Stack your goals. When you’re farming Helltides for Living Steel or hitting Legion Events for Exquisite Blood, pick zones where Husks are packed in. That way, you’re killing two birds with one stone—working toward your boss summon while sniping at the gear slot you want.

Over time, the extra percentage chance for drops stacks up. It’s all about efficiency. Spend an hour farming and you’re ticking two, maybe three boxes at once. In this game, the grind never stops, but if you play it smart, it pays off faster. And if you want to keep the momentum, it’s worth it to buy Diablo 4 Items to round out your build and keep pushing deeper into Sanctuary.